Berberine is an active constituent of many plants, including Phellodendron amurense root, goldenseal, Oregon grape root, and barberry. Research has shown that berberine has a unique and interesting function—it activates adenosine monophosphate protein kinase (AMPK).* AMPK is activated through various mechanisms, including exercise, to support glucose metabolism via an insulinindependent mechanism. Berberine has been the subject of several human, randomized placebo-controlled trials to study its effects and learn more about its benefits. More recent characterization and isolation of the main active constituent, berberine, has led to the development of Berberine hydrochloride as a supplement.

Health Benefits of Berberine:
• Promotes healthy blood sugar and insulin metabolism*
• Aids healthy metabolic function*
• Supports healthy cardiovascular function and lipid metabolism*
• Promotes healthy insulin receptor expression, with direct impact on supporting healthy glucose metabolism*
• Supports healthy regulation of glycation*

Clinical Studies
Berberine is an isoquinoline alkaloid isolated from various plants, which have been used traditionally to support gastrointestinal health— primarily in Asia.* Berberine has also been used to support blood sugar metabolism in traditional Chinese medicine for centuries. In the modern development of evidence, several controlled clinical trials have shown the benefits of berberine in various conditions as compared to reference or placebo. Pre-clinical trials provide further understanding of its numerous mechanisms of action.

One randomized, double-blind trial compared a placebo to berberine for metabolic function.* Twenty-four study participants received a placebo or 500 mg of berberine hydrochloride, 3 times per day prior to meals. After 12 weeks, berberine was shown to support healthy insulin sensitivity, promote healthy blood sugar and insulin metabolism, and aid healthy metabolic function.

In an additional study, thirty-six adults received berberine at a dose of 500 mg, 3 times per day. After 3 months, berberine supported healthy blood sugar and insulin metabolism, regulation of glycation, and healthy cholesterol metabolism.

A lower dose was used in a larger study. In that study, 116 subjects were provided either 1 gram per day of berberine or a placebo. After 3 months, berberine was shown to promote healthy insulin receptor expression, with direct impact on glucose metabolism.

Scientists evaluated the effects of 1,500 mg per day of berberine on humans and Sprague-Dawley rats. They found that it supports healthy metabolic function and lipid metabolism.

Berberine by Integrative Therapeutics offers a concentrated 500 mg dose of the isolated extract berberine HCl. The Berberine Complex provides a combination of berberine-containing herb extracts, such as barberry, Oregon grape, and goldenseal, which can enhance the absorption and utilization of berberine.* Berberine has been shown to exhibit activity in maintaining healthy intestinal flora. Their formula was designed to help maintain a healthy intestinal tract by supporting a healthy balance of bacteria in the digestive tract, which also supports the immune system.*

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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