Purpose: Although it is widely recognized that caregivers of individuals with dementia experience elevated stress that places them at increased risk for health problems, little is known about how caregiv-ing stress may be alleviated among underserved eth-nic minority populations. The purpose of this study was to compare a complementary and alternative medicine therapy, polarity therapy (PT), to an en-hanced respite control condition (ERC) to reduce stress and depression and improve quality of life for American Indian (AI) and Alaskan Native family caregivers. Design and Methods: Forty-two AI family caregivers of individuals with dementia, liv-ing on and off reservations in the Pacifi c Northwest, were randomized to an 8-session trial of PT or ERC. PT is a touch therapy that uses gentle pressure on energy points and biofi elds to help the client achieve physiological relaxation. ERC included respite care for the person with dementia and a choice of activi-ties for the caregiver. Average age of caregivers was 50 years (range 27 –69 years); 90% were wom-en; 52% daughters, 10% wives, 7% sons, and 31% other relatives. Outcome assessments administered